IT HAPPENS ONLY IN INDIA,
GREAT JOB MR. PARMAR
it is good to eat as many as vegetables and fruits (totally vegetarian), but my aurvedic doctor asked me to stop eating every...
an experimental vaccine against the lethal Ebola virus has been administered to humans for the first time in November 2003. If the trial proves successful, then the vaccine will be commercialised by 2006, a decade sooner than the time, it was thought, it would take to develop the inoculation. The potential to use the virus as a bioterrorism weapon is one of the major factors determining the speed at which the vaccine was developed. It can also be used as a preventive tool in countries where the virus is endemic.
It is the first of two vaccines being developed by researchers from the us-based National Institutes of Health (nih). During tests on monkeys in 2000, it was found to be 100 per cent effective. The human trial would involve 27 volunteers. Six of them would be given a placebo. The rest will receive three injections during two stages of the treatment. In the first stage, the immune system will be 'primed' by the direct injection of non-infectious genetic material of the virus. The presence of the genetic material will initiate the production of antibodies against the virus on a large-scale.
During the second stage, the immune system's response will be 'boosted' with the help of the two other jabs, which contain the common cold-causing viruses genetically modified to incorporate the genetic material of the Ebola virus. The material is incorporated in the common cold viruses so that it can be replicated when they multiply. If the Ebola virus attacks the person in future, then his/her immune system will have a 'memory' of the virus; this will help in quickly producing the desired immunity. In an unvaccinated person, the production of antibodies would be slower than what is required.
The researchers claim that their vaccine is safe, as it does not contain any infectious material from the virus. However, there is a hitch -- the human body is accustomed to attacks by the common cold virus, and hence it may not produce the antibodies if the virus is injected several times. Two people have been given the vaccine to date. All the subjects will be followed up for one year. The researchers would collect blood samples to measure the type and duration of the immune system's response. The subjects would not be infected by the virus to gauge the effectiveness of the treatment as it is too risky to do so.
But without the fear of bioterrorism, the inoculations would even be a far-fetched dream, as is the case with many other diseases that plague the developing world. Even though large sums of money have been invested in the development of vaccines against malaria, kala azar and aids, their success has been limited. The new vaccines will prove to be the much needed tool to combat the virus, especially for the most affected African countries. The disease is characterised by haemorrhagic fever, followed by diarrhoea, vomiting, stomach ache and ultimately death.