Stanford University researchers, by studying what are known as DNA microsatellites, try to explain the genesis and evolution of the Homo sapiens - Providing yet another proof in support of the 'Out of Africa' theory
THE question of the origin of modern
human beings - Homo sapiens - has
been the cause for considerable debate
in the past. One hypothesis goes by the
name of 'Multi-regionat theory of
human evolution'. As the name suggests, it contends that our ancestral
species, the Homo erecrus, spread to different parts of the world over one million years ago, and that the Homo sapiens evolved gradually and in parallel in
these places. Regular genetic exchange
ensured that the same species evolved in
different locations. At,the same time,
local differences remained to a fair
degree; these, so the assertion goes, are
still to be found in the human races of
today.
The second hypothesis is called the
'Out of Africa' theory. According to it,
Homo sapiens originated in Africa
between 100,000-200,000 years ago and
then migrated worldwide. The two
points of view agreed on one thing -
that all humans descended from African
ancestors. There is an essential distinction, however. The first theory says our
last common African relative lived a
million years ago and belonged to
another species; the second says that our
African Adams and Eves were around
much more recently, and besides, were
one of us'.
To a great extent, the debate has
been fuelled by findings on variations in
human DNA. One assumes a certain rate
of change in the letters that constitute
the same DNA molecule in the two
groups of humans that we wish to compare. Then one estimates the extent of
change by calculating the most likely
genetic distance covered between the
last common ancestor and the two
representative samples. Knowing the
Tate and the distance immediately
gives us a measure of the time since
divergence.
A Fictitious example might help. It is
known that when the same language is
used in widely separated areas, spellings
tend gradually to drift. Say, the average
rate of drift works out one letter in 100
years. Suppose there are two given
spellings for the'same word, such as
'lapbit' and 'robbet'. it would be a reasonable, therefore, to draw an inference
which would point to the fact that the
two must have shared a common ancestor and that the ancestral word was,
probably, 'rabbit'.
D B Goldstein, L L Cavalli-Sforza
and colleagues at Stanford University,
us, have taken a fresh took at the
problem by collecting information on
what are known as DNA microsatellites.
These are very short segments of
DNA which tend to be repeated one
after another a large number of times.
It appears that they have no significant functional role to play, because
their sequences - the 'letters in
the word' - drift randomly but
with the clocklike regularity expected
of anything which evolves as fast as
it mutates.
By applying a new measure of molecular distance, Goldstein and colleagues
studied 30 microsatellites in 14 human
populations and constructed a tree
of relationships. The toot of their
constructed tree separates Africans
from all non-Africans, suggesting first
of all that the primeval sequence was
closest to that found in modern-day
Africans.
Next, using available information
on the rate of mutation in the
microsatellites that they looked at, they
came up with a figure of 156,000 years
as the best estimate for the time since
African and non-African populations
diverged. This offers yet another piece
ofsupport to the proponen ts of the 'Out
of Africa' theory (Proceedings of the
National Academy of Sciences of the USA,
Vol 92, 1995).
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