Protein from buffalo blood has answer to infertility

 
By Biplab Das
Published: Monday 15 January 2007

Boosting fertility (Credit: Pradip Saha / CSE)a protein isolated from buffalo blood induces forward motility of goat sperm, an essential quality that makes fertilisation possible in animals and humans, claims a research team from the Indian Institute of Chemical Biology, Kolkata. Known as the forward motility stimulating factor (fmsf), it has been shown to activate goat spermatozoa.

"fmsf can be used to enhance fertility in animal breeding farms and human infertility clinics," says Gopal Chandra Majumder, the lead author. "The motility-promoting efficacy of fmsf is higher than non-protein activators like theophylline and bicarbonate. Besides, it is not species specific," Majumder adds. fmsf, according to him, also has the potential for improving breeding of wild animals, and should help species that are almost extinct or endangered.

After isolation from buffalo blood fluid, fmsf was purified and exposed to goat sperm incubated in plasma. The team found two types of fmsf (fmsf-i, fmsf-ii). Nearly 20-30 per cent goat spermatozoa showed forward progression in the absence of fmsf-i. The addition of it enhanced sperm forward motility significantly.

"The motility-promoting action is nearly complete in about one minute compared to other motility-promoting factors (theophylline and bicarbonate), which take six minutes to initiate maximal forward motility of sperm," says Majumder. Mostly synthesised in liver, fmsf-i stimulates the motility of sperm of goat, rat and humans. This shows that it has a certain regulatory role on sperm physiology. fmsf-i contains protein and sugar, both of which contribute to its motility-promoting factor, he says.

"Study reveals that fmsf-i binds to the receptor protein on sperm cell surface, which activates a second messenger protein, which in turn triggers a cascade of cellular events inside the sperm, inducing forward motility," explains Majumder in a paper published in the November issue of Journal of Cellular Physiology (Vol 209, No 2).

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