Vitamin C could be panacea for drug-resistant TB

Vitamin triggers reaction which eventually kills off bacteria; could help shorten drug therapy
Vitamin C could be panacea for drug-resistant TB

An unexpected discovery can bring relief to millions of people suffering from multi-drug resistant tuberculosis (MDR-TB) across the globe. A study by an American research team reports that vitamin C can kill the bacteria Mycobacterium tuberculosis that causes MDR-TB.

The report published on Tuesday says, “Vitamin C, a compound known to drive the Fenton reaction, sterilizes cultures of drug-susceptible and drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis.”

Researchers at the Albert Einstein College of Medicine, New York, found that the vitamin C effectively kills drug-resistant TB bacteria under laboratory conditions. It also suggests that vitamin C can shorten the duration of drug therapy.

Domino effect

In a statement, the college mentioned that the discovery was made during research into how TB bacteria become resistant to isoniazid, a potent first-line TB drug. The research team observed that isoniazid-resistant TB bacteria were deficient in a molecule called mycothiol.

Drug resistance decoded
 
Multi-drug-resistant TB (MDR-TB): TB that does not respond to isoniazid and rifampicin, the two most potent anti-TB drugs

Extensively drug-resistant TB (XDR-TB): TB that is resistant to rifampicin and isoniazid, as well as to any member of the quinolone family of antibiotics and at least one of four second-line injectable anti-TB drugs
 

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