Malaria, prevalent in over 100 countries, poses a risk to some 2,700 million people across the world. Poor health infrastructure and drastic ecological changes have favoured transmission of the malaria parasite, which has developed an immunity even to less widely used drugs. Though vaccines that may affect the parasite's ability to invade human and mosquito cells are being tested and developed, a 'wonder' vaccines is not enough to curd the spread of malaria. The second wave of the disease in the 1970s was distinct, a third wave may not. Unless concerted strategies in keeping with local conditions are implemented globally nature may beat technology again