Health

Study offers potential diagnostic & therapeutic tools for fatty-liver-induced diabetes

Non-Alcoholic Fatty Liver Disease and Type 2 diabetes has been increasing rapidly in India

 
By India Science Wire
Published: Wednesday 07 September 2022
The researchers analysed blood samples from fat-fed mice and human NAFLD patients. Representative Photo: India Science Wire
The researchers analysed blood samples from fat-fed mice and human NAFLD patients. Representative Photo: India Science Wire The researchers analysed blood samples from fat-fed mice and human NAFLD patients. Representative Photo: India Science Wire

A new study by a team of researchers from several Indian institutions has unraveled the biochemical relationship between fatty liver disease and Type 2 Diabetes Mellitus (T2DM). This understanding is expected to help develop newer tools for diagnosing and treatingfatty liver-induced diabetes.

The study assumes importance as the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Type 2 diabetes has been increasing rapidly in India. Recent surveys show that 40 per cent of Indian adults suffer from NAFLD and nearly 50 million Indian adults have both NAFLD and type 2 diabetes.

The study team consisted of researchers from the Indian Institute of Technology Mandi, CSIR-Indian Institute of Chemical Biology, Kolkata, and the Institute of Post Graduate Medical Education & Research (SSKM Hospital), Kolkata. They have published a report on their findings in the scientific journal Diabetes.

Explaining the significance of their work, the researchers noted that NAFLD affecting the function of insulin-releasing pancreatic β-cell was a known fact. But, the mechanism was not fully understood. The new study has filled the gap.

The researchers analysed blood samples from fat-fed mice and human NAFLD patients.  Both sets of serum samples were found to have high amounts of a calcium-binding protein termed S100A6, and further studies showed that it was inhibiting insulin secretion.More studies showed that depletion of the protein improves insulin secretion and blood glucose regulation in mice.

The researchers said that the study was critical on many counts.  From a diagnostic angle, it shows that elevated levels of S100A6 protein in the blood may serve as a biomarker to identify risks of T2DM among NAFLD patients.At a therapeutic level, it showed that removing it from blood can help restore insulin secretion.

The team consisted of Dr Prosenjit Mondal, Associate Professor, School of Biosciences and Bioengineering, IIT Mandi, with his scholars Surbhi Dogra, Priya Rawat, Dr P Vineeth Daniel, Dr Partha Chakrabarti from CSIR-Indian Institute of Chemical Biology, Kolkata and his colleagues Dr DebajyotiDas, Sujay K Maity, and Avishek Paul and Dr Kausik Das and Dr Souveek Mitra from IPGMER and SSKM Hospital, Kolkata. (India Science Wire)

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